Peptide Clinical Dosing Protocols

Peptide Clinical Dosing Protocols

GLP-1 Receptor Agonists

Peptide	Indication	Starting Dose	Maintenance Dose	Route	Frequency
Semaglutide (Ozempic)	T2DM	0.25 mg	0.5-2 mg	SC	Weekly
Semaglutide (Wegovy)	Obesity	0.25 mg	2.4 mg	SC	Weekly
Liraglutide (Victoza)	T2DM	0.6 mg	1.2-1.8 mg	SC	Daily
Liraglutide (Saxenda)	Obesity	0.6 mg	3.0 mg	SC	Daily
Exenatide (Byetta)	T2DM	5 mcg	10 mcg	SC	BID
Dulaglutide (Trulicity)	T2DM	0.75 mg	1.5-3 mg	SC	Weekly

Insulin Analogs

Peptide	Type	Starting Dose	Titration	Route	Frequency
Insulin glargine	Long-acting	10 units	2 units q3d	SC	Daily
Insulin degludec	Ultra-long	10 units	2 units q3d	SC	Daily
Insulin lispro	Rapid-acting	Per meal	Per glucose	SC	With meals
Insulin aspart	Rapid-acting	Per meal	Per glucose	SC	With meals

GnRH Analogs

Peptide	Indication	Dose	Route	Frequency
Leuprolide	Prostate cancer	7.5 mg	IM	Monthly
Goserelin	Breast cancer	3.6 mg	SC implant	Monthly
Triptorelin	Precocious puberty	0.25 mg	SC	Monthly

Somatostatin Analogs

Peptide	Indication	Starting Dose	Maintenance	Route
Octreotide	Acromegaly	50 mcg	100-500 mcg	SC TID
Lanreotide	Acromegaly	60 mg	60-120 mg	SC monthly
Pasireotide	Cushing’s	0.6 mg	0.6-0.9 mg	SC BID

Dose Adjustment Rules

1. Start low, go slow for all peptides
2. Titrate based on response (glucose, IGF-1, symptoms)
3. Monitor for side effects at each dose escalation
4. Adjust for renal impairment (eGFR <30: reduce dose 50%)
5. Adjust for hepatic impairment (Child-Pugh C: avoid or reduce)