Peptide Excipient Compatibility
Peptide Excipient Compatibility
Section titled “Peptide Excipient Compatibility”Common Excipients
Section titled “Common Excipients”| Excipient | Purpose | Compatible Peptides | Notes |
|---|---|---|---|
| BAC (0.9%) | Antimicrobial | Most peptides | Standard preservative |
| Mannitol | Bulking agent | All | Lyophilization aid |
| Sucrose | Cryoprotectant | All | Stabilizes during freeze-dry |
| Tween 80 | Surfactant | Aggregation-prone | Reduces surface adsorption |
| EDTA | Chelator | Metal-sensitive | Prevents metal-catalyzed oxidation |
| Glycine | Tonicity agent | Injectable | Adjusts osmolality |
Compatibility Testing
Section titled “Compatibility Testing”- Visual inspection — clarity, color, particulates
- pH measurement — stability of formulation pH
- Potency assay — bioactivity retention
- Aggregation — SEC-HPLC for aggregates
- Degradation — RP-HPLC for degradation products
Incompatible Combinations
Section titled “Incompatible Combinations”| Peptide | Incompatible | Reason |
|---|---|---|
| Insulin | Ethanol | Denaturation |
| Oxytocin | Strong acids | Hydrolysis |
| BPC-157 | None known | Highly stable |
| GHK-Cu | EDTA | Chelates copper |