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Peptide Database — Approved and Investigational Agents

This is a comprehensive database of peptides used in research, therapeutics, and biology. The database contains 795+ entries across 23 categories covering every major organism kingdom.

Approved drugs and clinical candidates including:

  • Diabetes: Insulin, GLP-1 agonists (semaglutide, liraglutide, tirzepatide)
  • Cancer: GnRH agonists/antagonists (leuprolide, degarelix, relugolix)
  • Infectious Disease: Antibiotics (vancomycin, daptomycin, colistin)
  • Cardiovascular: ACE inhibitors, neprilysin inhibitors, anticoagulants
  • Bone/Joint: PTH analogs, calcitonin
  • Neurology: Ziconotide, botulinum toxin

Toxins from venomous organisms with therapeutic potential:

  • Snake venoms: α-bungarotoxin, dendrotoxin, sarafotoxin, crotamine
  • Cone snail venoms: ω-conotoxin MVIIA (ziconotide), μ-conotoxin, α-conotoxin
  • Scorpion venoms: Chlorotoxin, charybdotoxin, iberiotoxin, margatoxin
  • Spider venoms: ω-agatoxin, huwentoxin, ProTx-II
  • Bee/wasp venoms: Melittin, apamin, mastoparan

Bioactive peptides from marine organisms:

  • Toxins: Tetrodotoxin, saxitoxin, palytoxin, ciguatoxin
  • Anti-cancer: Trabectedin, eribulin, dolastatin 10, kahalalide F
  • Drugs: Ziconotide, χ-conotoxin MrIA

Peptides from plant sources:

  • Defense: Thionins, defensins, snakins, heveins
  • Cyclic: Cyclotides (kalata B1, MCoTI, cycloviolacin)
  • Toxic: Abrin, ricin, modeccin, viscumin
  • Bioactive: Lunasin, Bowman-Birk inhibitor

Engineered and synthetic peptides:

  • Stapled: ALRN-6924, ATSP-7041 (MDM2/MDMX inhibitors)
  • Cyclic: Cilengitide, linaclotide, plecanatide
  • Drug Conjugates: Brentuximab vedotin, trastuzumab emtansine
  • Vaccines: NeuVax, suruvatide, GRANITE

Peptides from fungi:

  • Antibiotics: Penicillin, cephalosporin, echinocandins
  • Cyclopeptides: Amanitin, phalloidin, cordycepin
  • Lipopeptides: Nystatin, amphotericin B, natamycin

Peptides from bacteria:

  • Bacteriocins: Nisin, pediocin, leucocin, enterocin
  • Polymyxins: Polymyxin B, colistin
  • Glycopeptides: Vancomycin, teicoplanin, oritavancin
  • Lipopeptides: Daptomycin, surfactin

Peptides from insects:

  • Defensins: Insect defensins A/B, sapecin, royalisin
  • Cecropins: Cecropin A/B/D/P1
  • Hormones: PTTH, allatostatin, adipokinetic hormone
  • Venom: Melittin, apamin, mastoparan

Peptides from amphibians:

  • Antimicrobial: Magainin, brevinin, temporin, esculentin
  • Opioid: Dermorphin, deltorphin A/B/C/D
  • Neuropeptides: Bombesin, TRH, caerulein

Peptides from reptiles:

  • Snake venom: α-bungarotoxin, dendrotoxin, sarafotoxin
  • Lizard: Exendin-4 (GLP-1R agonist), helodermin
  • Crocodilian: Crocodilin, defensins

Peptides from mammals:

  • Bovine: Bactenecin, indolicidin, BMAP-28, lactoferricin B
  • Porcine: Protegrins, PR-39
  • Ovine: SMAP-29, OaBac5

Peptides from birds:

  • Defensins: Avian beta-defensins 1-5, gallinacins
  • Cathelicidins: Chicken, turkey, duck cathelicidins

Peptides from fish:

  • Antimicrobial: Piscidins, hepcidin, moronecidin, pleurocidin
  • Hormones: Salmon calcitonin, insulin, GH
  • Venom: Stonustoxin, trachynilin

Peptides from worms:

  • Nematode: FMRFamide peptides, insulin-like peptides (C. elegans)
  • Earthworm: Lumbricin, lumbrokinase
  • Leech: Hirudin (thrombin inhibitor)

Peptides from yeast:

  • Mating: a-factor, α-factor (S. cerevisiae)
  • Killer toxins: K1, K2, K28

Peptides from protists:

  • Algae: Microcystins, nodularins, anatoxins
  • Protozoan: Plasmodium, Trypanosoma peptides
  • Neuropeptides (30): Endorphins, enkephalins, substance P, CGRP, NPY
  • Antimicrobial (25): LL-37, defensins, magainin, colistin
  • Toxins (25): α-bungarotoxin, conotoxins, chlorotoxin
  • Food-derived (17): VPP, IPP, carnosine, glutathione
  • Cosmetic (15): Matrixyl, argireline, GHK-Cu, Syn-Ake
  • Biomarkers (20): BNP, troponin, amyloid-beta, PSA
CategoryCountKey Examples
Therapeutic93Semaglutide, insulin, oxytocin, leuprolide
Venom50α-bungarotoxin, ω-conotoxin, chlorotoxin
Marine35Tetrodotoxin, trabectedin, eribulin
Plant40Cyclotides, ricin, lunasin
Synthetic40ALRN-6924, cilengitide, brentuximab vedotin
Fungal35Penicillin, amphotericin B, cyclosporin
Bacterial35Nisin, vancomycin, daptomycin
Insect40Cecropins, melittin, apamin
Amphibian35Magainin, dermorphin, bombesin
Reptile40Exendin-4, helodermin, dendrotoxin
Mammalian40Bactenecin, protegrins, SMAP-29
Bird35Avian defensins, gallinacins
Fish35Piscidins, salmon calcitonin
Worm40Hirudin, lumbricin, FMRFamide
Yeast35a-factor, α-factor, killer toxins
Protist35Microcystins, saxitoxin
Other137Neuropeptides, antimicrobial, toxins, food, cosmetic, biomarkers
Total795